Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025Brain and BehaviorOpen Access

Unveiling the Relationship Between Oral Microbiota and Alzheimer's Disease: A Genetic Instrumental Variable Analysis via Mendelian Randomization

View Full Paper
Ask AI
Bookmark
Share

Authors

ZLZhichao LiShandong University of Traditional Chinese MedicineYKYihan KangFourth Affiliated Hospital of China Medical UniversitySLShuai LiQingdao University

Discussion

Loading...

Member takes

Implication

Mendelian randomization analysis reveals significant associations between oral microbiota and Alzheimer's disease, suggesting potential treatment targets.

Key Points

  • Causal relationship identified between oral microbiota and alzheimer's disease, with significant findings for 48 exposures.
  • Thirty exposures linked at the genus level and twelve at the species level illustrate the complexity of microbial influences.
  • Analysis utilized two-sample mendelian randomization, leveraging genome-wide association study summary statistics for robust effect estimates.
  • Findings support the idea that oral microbiota may play a role in the pathogenesis of alzheimer's disease, calling for further exploration.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68c1b34654b1d3bfb60e961chttps://doi.org/10.1002/brb3.70753
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Subgingival microbiome and clinical periodontal status in an elderly cohort: The WHICAP ancillary study of oral health2020 · 70 citations
  2. 2clusterProfiler 4.0: A universal enrichment tool for interpreting omics data2021 · 13,254 citations
  3. 3Metagenome-genome-wide association studies reveal human genetic impact on the oral microbiome2021 · 129 citations
  4. 4Human campylobacteriosis: A public health concern of global importance2019 · 337 citations
  5. 5Periodontal dysbiosis associates with reduced CSF Aβ42 in cognitively normal elderly2021 · 45 citations