Association of Interleukin-10 gene polymorphisms (rs1800872 and rs1800896) with cervical cancer susceptibility in Quetta, Pakistan

Background. Interleukin-10 (IL-10) regulates immune responses and has been linked to cancer development. Polymorphisms in the IL-10 gene, such as rs1800872 and rs1800896, may affect cancer susceptibility. No previous study has examined the association between these variants and cervical cancer in Quetta, Pakistan, which this study aims to address. Aims. This study aimed to investigate the association between IL-10 gene polymorphisms (rs1800872 and rs1800896) and cervical cancer susceptibility among women in Quetta, Pakistan, and to determine the prevalence and risk factors contributing to cervical cancer in this population. Material and Methods . A total of 50 patients diagnosed with cervical cancer and 50 individuals without any health issues were selected for the case-control analysis. Data was collected for retrospective analysis using a pre-designed data collection form. Demographic information and blood samples were collected from participants with explicit consent. The DNA was extracted using an organic approach, and genotyping was performed using the TETRA primer ARMS-PCR technique. The data analysis was conducted using multinomial logistic regression with a 95 % confidence interval, utilizing the SPSS software. Results. The study demonstrated no significant association between IL-10 gene polymorphisms (rs1800872 and rs1800896) and cervical cancer among the population of Quetta City. Statistically significant relationships were found between cervical cancer and smoking, lack of exercise, menarche, and usage of oral contraceptive medications. Conclusion . This study confirms no association between IL-10 gene polymorphisms (rs1800872 and rs1800896) and cervical cancer in Quetta. Furthermore, a lack of awareness regarding cervical cancer poses a significant obstacle to its effective care at the individual level in Pakistan.