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September 10, 2025Frontiers in ImmunologyOpen Access

Development and validation of nomogram for predicting pathological complete response to neoadjuvant chemotherapy and immunotherapy for locally advanced gastric cancer: a multicenter real-world study in China

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Authors

HCHao CuiRLRui LiLSLiqiang Song

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Overview

Multicenter analysis identifies key predictors of pathological complete response in gastric cancer, suggesting valuable decision-making tool for clinicians.

Key Points

  • The nomogram demonstrated strong predictive ability, with an AUC of 0.934 for the validation set.
  • Independent predictors for pathological complete response include age, tumor diameter, and CEA levels.
  • Logistic regression models were used to evaluate factors influencing the prediction of pathological complete response.
  • This model could enhance personalized treatment strategies for patients receiving neoadjuvant chemotherapy and immunotherapy.

Cite This Study

Cui et al. (2025) studied this question.

synapsesocial.com/papers/68c1b34d54b1d3bfb60e9c18https://doi.org/10.3389/fimmu.2025.1603196
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Development and analysis of a nomogram for predicting pathological response to neoadjuvant immunochemotherapy in locally advanced gastric cancer2026 · 1 citations
  2. 2Construction and validation of a predictive model for the efficacy of neoadjuvant chemotherapy combined with immunotherapy in locally advanced gastric cancer: a single-center retrospective study2025
  3. 3Nomogram for predicting pathological response to neoadjuvant treatment in patients with locally advanced gastric cancer: Data from a phase <scp>III</scp> clinical trial2024 · 5 citations
  4. 4Development of a predictive model for pathological complete response following neoadjuvant immunotherapy and chemotherapy in locally advanced resectable esophageal squamous cell carcinoma2026
  5. 5A dynamic nomogram for predicting pathologic complete response to neoadjuvant chemotherapy in locally advanced rectal cancer2024 · 2 citations