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September 10, 2025Frontiers in ImmunologyOpen Access

Langerhans cells drive Tfh and B cell responses independent of canonical cytokine signals

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Authors

ABAurélie BouteauThomas Jefferson UniversityZQZhen QinWenzhou UniversitySZSandra ZurawskiInserm

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Implication

Observational analysis reveals Langerhans cells drive Tfh and B cell responses, indicating novel immune pathways.

Key Points

  • Langerhans cells promote T follicular helper (Tfh) and B cell responses in a steady-state environment, without relying on canonical cytokine signals.
  • Key findings demonstrate that these immune responses are driven by CD80/CD86-mediated co-stimulation rather than interleukin-6 or other typical inflammatory signals.
  • This study utilized multiple mouse models and in vitro systems to explore the role of Langerhans cells in adaptive immunity under non-inflammatory conditions.
  • The findings may reshape understanding of how homeostatic immunity operates and its implications for autoimmune diseases.

Cite This Study

Bouteau et al. (2025) studied this question.

synapsesocial.com/papers/68c1b35454b1d3bfb60e9cf0https://doi.org/10.3389/fimmu.2025.1611812
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