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September 10, 2025Asian Journal of Biotechnology and Bioresource TechnologyOpen Access

Neurological Side Effects of Long-term Botulinum Toxin Use

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Authors

GOGiovanna OliveiraVSVanessa Emanuelle Cunha SantosEscola Bahiana de Medicina e Saúde PúblicaCCCármen CarvalhoAdministração Regional de Saúde de Lisboa e Vale do Tejo

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Overview

Qualitative review reveals potential neurological side effects of botulinum toxin in patients, suggesting implications for monitoring.

Key Points

  • Botulinum toxin type A is generally effective for motor conditions but may cause mild to moderate side effects.
  • Long-term use is linked to neurological side effects such as fatigue and muscle weakness, necessitating cautious monitoring.
  • Chronic migraine treatment with botulinum toxin A showed significant improvement in pain and quality of life outcomes.
  • Further research is crucial to understand central mechanisms involved in the long-term use of botulinum toxin.

Cite This Study

Oliveira et al. (2025) studied this question.

synapsesocial.com/papers/68c1b35454b1d3bfb60ea00ehttps://doi.org/10.9734/ajb2t/2025/v11i3246
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Therapeutic Applications of Botulinum Neurotoxin: Insights from a Comprehensive Literature Review2024
  2. 2Long-Term Management of Post-Stroke Spasticity with Botulinum Toxin: A Retrospective Study2024 · 9 citations
  3. 3The Impact of Strength Changes on Active Function Following Botulinum Neurotoxin-A (BoNT-A): A Systematic Review2025
  4. 4Off-Label Therapeutic Usage of Botulinum Toxin Intramuscular Injections in the Head and Neck: A Scoping Review2026
  5. 5Adverse Drug Reaction Study of Botulinum Toxin‐A in the Real World2026