Case report shows complete resolution of recurrent clostridioides difficile infection using fecal microbiota transplantation, indicating tailored strategies for chronic colitis patients.
Recurrent Clostridioides difficile infection (rCDI) remains a significant treatment challenge, particularly in patients with underlying gastrointestinal conditions. We present the case of a 72-year-old woman with multiple sclerosis and sarcoidosis, who experienced four separate episodes of rCDI despite treatment with vancomycin, fidaxomicin, and intravenous metronidazole. Colonoscopy revealed patchy inflammation with aphthous ulcerations, and histology confirmed chronic colitis without dysplasia or cytomegalovirus infection. Following a structured vancomycin taper, the patient underwent fecal microbiota transplantation (FMT), with complete resolution of symptoms. This case supports the early use of FMT in rCDI and highlights the need for individualized treatment strategies in patients with co-existing colonic inflammation.
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Hamad et al. (2025) studied this question.
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