Synthesis of surfactants containing alkyl-sugar triazoles shows moderate antibacterial activity against E. coli and Staphylococcus aureus, indicating potential for further development.
Two surfactants containing alkyl-sugar 1,4-disubstituted triazoles glycoconjugates were synthesized via Cu(I) catalyzed click conditions between azido alkane(C7,C8) and D-mannose based bis –O- propynyl ether. The latter was prepared via Williamson etherification between propargyl bromide and the2C-branched-D-mannose diacetonide which was synthesized in a previous work by aldol condensation between formaldehyde and the protected sugar in MeOH. The two surfactants have been examined in vitro by inhibition of bacteria growth ( Escherichia coli and staphylococcus aureus) and showed a moderate activity. The two prepared surfactants were purified by column chromatography and identified by TLC, FTIR, 1HNMR , 13CNMR, 2D-NMR correlation COSY and HSQC.
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Lamyaa Salih Mahdi (2025) studied this question.
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