Observational analysis identifies kidney injury risks in patients treated with mefenamic acid, highlighting NSAIDs role.
Mefenamic acid is a non-selective non-steroidal anti-inflammatory drug (NSAIDs) used in the management of pain and inflammation. They are non-opioid analgesics. They inhibit the synthesis of prostaglandins in body tissues by inhibiting COX-1 and COX-2. Thus inhibits the synthesis of prostaglandins, reducing blood supply to the kidneys. Hence, there is always a possibility of kidney injury after administration of Mefenamic acid. We hereby present a series of 7 patients where they developed kidney injury while on treatment with Mefenamic acid.
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Wilson et al. (2025) studied this question.
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