This study demonstrates significant hepatoprotective effects of Erythroxylum and Eugenia extracts against acetaminophen-induced injury in HepG2 cells, suggesting natural therapeutic options.
Objectives Liver injury is a major global public health concern. Despite advancements in modern medicine, there remains a pressing need to identify more effective and less toxic therapeutic options for managing liver diseases. This study aimed to assess the hepatoprotective potential of Erythroxylum daphnites Mart., Erythroxylum suberosum A.St.-Hil., Eugenia dysenteria (Mart.) DC., Pouteria torta (Mart.) Radlk., and Pouteria ramiflora (Mart.) Radlk. against acetaminophen (APAP)-induced injury in human hepatocarcinoma (HepG2) cells. Methods The hepatoprotective potential of the extracts was evaluated in HepG2 cells using APAP as the injury-inducing agent. Additionally, the chemical composition of the extracts was analyzed using high-performance liquid chromatography coupled with diode-array detection (HPLC-DAD). Results Chemical analysis of the plant extracts revealed the presence of polyphenolic compounds, including flavonoids and phenolic acids. All tested extracts exhibited a significant protective effect against APAP-induced cell death in both pre-treatment and post-treatment protocols. Conclusion This study highlights the potential of natural products from the Cerrado biome as hepatoprotective agents. The observed protective effects are likely attributed to the diverse chemical compounds present in these extracts.
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Leão et al. (2025) studied this question.
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