This synthesis demonstrates effective asymmetric (4+2)-cycloadditions using chiral isochalcogenoureas, showing enhanced enantioselectivity and regioselectivity.
We herein report the use of ethyl but-3-ynoate as a C2 building block for asymmetric (4+2)-heterocycloadditions with various Michael acceptors. Upon using chiral isochalcogenoureas as Lewis base catalysts, these reactions can be carried out with good to excellent control of the regioselectivity, diastereoselectivity, and enantioselectivity.
No takes yet. Share an insight, caveat, or question.
Hofer et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: