Real-world User-reported Benefits of a Multi-ingredient NMN-based Supplement Targeting Age-related Decline: A Brief Report

The age-related decline in nicotinamide adenine dinucleotide (NAD⁺) contributes to mitochondrial dysfunction and oxidative stress, which may be mitigated by supplementation with NAD⁺ precursors such as nicotinamide mononucleotide (NMN). This retrospective observational study evaluated user-reported outcomes of a multi-ingredient supplement (NMN, hydroxytyrosol, ergothioneine, resveratrol, and vitamin D₃) using 196 self-reported experiences collected from the Wonderfeel Biosciences online platform (April 2022–September 2024). Among 196 analyzed users, 131 (66.8%) reported positive effects, primarily in the nervous (81%), integumentary (11%), muscular (4%), skeletal (2%), digestive (2%), and endocrine (1%) systems, while 31.6% noted neutral effects and 1.5% reported non-causal adverse events. These findings align with known mechanisms of NAD⁺ restoration and oxidative stress mitigation, suggesting complementary biological pathways. Although this real-world evidence highlights perceived improvements in energy, cognition, sleep, and skin health, the study’s limitations—including self-reported data, lack of demographic controls, and absence of biomarkers—necessitate confirmation through the prospective controlled clinical trial scheduled to commence in late 2025.