Efficient computation of high-amplitude acoustics in the body: From ultrasound to noise

We present computational and experimental results for appreciating the biological effects of high-amplitude acoustics. This talk focuses on two problems with shared motivation. We represent the damage of noise to ear drums via vorticity production from broadband acoustic fields. Scale-resolved simulations identify the mechanisms that introduce harmful noise levels in purportedly well-fit ear plugs. Similarly, we present a strategy for optimal experimentation that identifies the material properties of soft, biological materials at high strains. A Bayesian strategy is buttressed by data assimilation and computer simulation. With these tools, we parameterize models for biological matter that otherwise require expensive experimentation via only a few simulations. Equipped with this information, we reliably distinguish between good and poor models and validate against simulation-unseen established experiments. A method for classifying the otherwise unknown biomaterial response is presented. Simulation-aided ablation treatment of biologically formed stones and malignant tissues via non-invasive biomedical ultrasound is also discussed.