Synthesis of Some Novel Oxazoles and Their Application for Antimicrobial Activity

Unique property of easy binding with a wide spread spectrum of receptors and enzymes in biological systems through various non- covalent interaction oxazole based molecules are becoming a kind of significant heterocyclic nucleus and have received attention for researchers globally, leading them to synthesize diverse Oxazole derivatives. Taking this into consideration an attempt has been made to synthesize some new 4-substituted 2-(benzoyl) oxazole-5-ones derivatives by reaction of benzoyl glycine with different quinoine ether. The synthetic root of 4-substituted 2-(benzoyl) oxazole-5-ones involves the reaction between benzoyl glycine and different aldehyde with Erlenmeyer reaction reagent (acetic anhydride and sodium acetate). The structure of synthesized compound has been established on the basis of qualitative analysis. The synthesized compound is also employed for antimicrobial, antibacterial and antioxident activitites. Initial results are very encouraging, antioxidant properties of synthesized substituted oxazole (8a-c) and (4a-c) were found to be quite matching with test standard ascorbic acid. In case of antimicrobial activity, (8b) is found moderately active against S. aureus, E. coli, X. Oxalopodis, S. Typhi whereas inactive against E. Erwinia.