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September 10, 2025The Journal of the Acoustical Society of America

Cellular trouble for cavitation dose monitoring in microbubble-mediated drug delivery?

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Authors

KKKlazina Kooiman

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Overview

Observational analysis reveals microbubble oscillation affects drug delivery efficacy, suggesting complexity in cellular interactions.

Key Points

  • Microbubble oscillation above a threshold is necessary for effective drug delivery to tissues, influencing cellular interactions.
  • Cell membrane pore formation, or sonoporation, facilitates drug delivery but shows no clear distinction in microbubble behavior predicting its occurrence.
  • Finding that cytoskeleton F-actin organization plays a crucial role in cell–cell contact opening highlights important cellular mechanisms involved.
  • Need for assessing higher acoustic pressures for transendothelial delivery supports the complexity in drug delivery using microbubble technology.

Cite This Study

Klazina Kooiman (2025) studied this question.

synapsesocial.com/papers/68c1b60654b1d3bfb60eade4https://doi.org/10.1121/10.0037525
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ultrasound-activated microbubbles mediate F-actin disruptions and endothelial gap formation during sonoporation2024
  2. 2Three-dimensional array of microbubbles sonoporation of cells in microfluidics2024 · 1 citations
  3. 3Beyond total release: Fragment-resolved metrics for ultrasound microbubble-mediated drug delivery2026
  4. 4A bottom-up approach to understanding ultrasound mediated blood–brain barrier opening using long and short pulses2025
  5. 5Corked Microcapsules Enabling Controlled Ultrasound-Mediated Protein Delivery2024 · 1 citations