Experimental findings demonstrate RNA assembly driven by isocyanide activation in prebiotic settings, suggesting underpinning chemistry for early ribozyme emergence.
Nonenzymatic assembly of RNA from chemically activated building blocks, such as phosphorimidazolides, would have been essential for the emergence of ribozymes on the early Earth. We previously showed that ribonucleoside...
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Zhang et al. (2025) studied this question.
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