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This is a Observational study (also classified as: Animal Study).

September 10, 2025Brain Research BulletinOpen Access

Inhibition of Sirtuin 2 Enhances Autophagy and Restores Neuronal Function in Aged Hippocampal Neurons

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Intervention with AK7 improves cognitive performance and enhances autophagy in aged hippocampal neurons, suggesting potential for cognitive decline.

Sirtuin 2 inhibition improved cognitive performance in aged mice, indicating a promising intervention for cognitive decline.
Inhibition of SIRT2 reduced mTOR phosphorylation and enhanced autophagy markers, which are crucial for neuronal health.
Quantitative proteomic analysis identified significant dysregulation of proteins associated with age-related cognitive decline.
The study employed both in vivo and in vitro methods to confirm the role of SIRT2 and mTOR in aging-related neuronal dysfunction.

Zhang et al. (2025) studied this question.

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Intervention with AK7 improves cognitive performance and enhances autophagy in aged hippocampal neurons, suggesting potential for cognitive decline.