Reduced-Dose Versus Full-Dose Direct Oral Anticoagulants for Extended Treatment of Venous Thromboembolism: A Meta-Analysis of Randomized Controlled Trials
Meta-analysis compares efficacy and safety of reduced-dose direct oral anticoagulants and full-dose regimens, indicating significant bleeding risk differences.
Key Points
Reduced-dose direct oral anticoagulants effectively prevent recurrent venous thromboembolism and reduce bleeding risks compared to full-dose regimens.
The meta-analysis included five randomized controlled trials with a total of 8781 patients, providing robust evidence for dosing strategies.
Significant reductions in major and clinically relevant nonmajor bleeding were observed with reduced-dose direct oral anticoagulants.
Future research should focus on more randomized controlled trials with extended follow-up, especially in cancer patients, to confirm findings.