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December 8, 2025Frontiers in PharmacologyOpen Access

Full-dose versus reduced-dose comparison of direct oral anticoagulants for extended treatment of venous thromboembolism: a systematic review and meta-analysis of randomized controlled trials

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Authors

YLYun LiWCWan Cheng

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Overview

Meta-analysis shows reduced-dose anticoagulants effectively lower bleeding risks in venous thromboembolism, supporting current guidelines.

Key Points

  • Reduced-dose direct oral anticoagulants significantly lower the risk of major bleeding compared to full-dose anticoagulants, improving patient safety.
  • In analysis from 5 clinical trials involving 8,781 cases, reduced-dose DOAC did not significantly increase the risk of recurrent VTE or death.
  • Systematic review and meta-analysis used a random-effects model to report pooled treatment effects and 95% confidence intervals across studies.
  • Findings support the use of reduced-dose anticoagulation therapy and adherence to existing venous thromboembolism guidelines.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/693624984fa91c937236c13dhttps://doi.org/10.3389/fphar.2025.1708316
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reduced compared with standard dose direct oral anticoagulant for extended treatment of venous thromboembolism: A systematic review and meta-analysis2026
  2. 2Reduced-Dose Versus Full-Dose Direct Oral Anticoagulants for Extended Treatment of Venous Thromboembolism2025 · 1 citations
  3. 3Reduced-Dose Versus Full-Dose Direct Oral Anticoagulants for Extended Treatment of Venous Thromboembolism: A Meta-Analysis of Randomized Controlled Trials2025
  4. 4Efficacy and safety of reduced-dose versus full-dose direct oral anticoagulants for extended treatment of venous thromboembolism: A meta-analysis with trial sequential analysis and reconstructed time-to-event data2025
  5. 5Reduced Versus Full-Dose Direct Oral Anticoagulants for Long-Term Management of Venous Thromboembolism: A Systematic Review2026 · 2 citations