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September 10, 2025International Journal of Molecular SciencesOpen Access

Comparative Evaluation of ARB Monotherapy and SGLT2/ACE Inhibitor Combination Therapy in the Renal Function of Diabetes Mellitus Patients: A Retrospective, Longitudinal Cohort Study

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Authors

ANA. NgaiABAqsa BaigMZMuhammad Anjum Zia

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Overview

Retrospective cohort study finds ARB monotherapy slightly improves renal function over SGLT2i/ACEi, suggesting treatment considerations.

Key Points

  • ARB monotherapy was associated with better renal function markers than SGLT2i/ACEi therapy, with higher eGFR and lower serum creatinine levels.
  • In this longitudinal study, 60.8% of ARB users maintained negative albuminuria compared to 73.1% on combination therapy, indicating renal stability.
  • With a sample of 126 patients, renal biomarkers were rigorously analyzed using t-tests and ANOVA to derive comparative effectiveness.
  • These results emphasize the need for further studies to understand the long-term renal effects of varying diabetes treatment regimens.

Cite This Study

Ngai et al. (2025) studied this question.

synapsesocial.com/papers/68c1b61454b1d3bfb60eb55fhttps://doi.org/10.3390/ijms26157412
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