8-Hydroxy quinoline catalysed regioselective synthesis of 1,4-disubstituted-1,2,3-triazoles: Realizing Cu-free click chemistry

Surbhi Bansal; R Gopika; Ayanangshu Biswas; Ashwani Sharma; G. Devika; Debashis Adhikari; Sanjay Singh

doi:10.1039/d5cy00598a

January 1, 2025Catalysis Science & TechnologyOpen Access

8-Hydroxy quinoline catalysed regioselective synthesis of 1,4-disubstituted-1,2,3-triazoles: Realizing Cu-free click chemistry

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Key Points

The study achieves a Cu-free synthesis of 1,4-disubstituted triazoles using 8-hydroxy quinoline as a catalyst, enhancing its pharmacological application.
Notably, the reaction demonstrates improved regioselectivity in the synthesis process, with results indicating a more efficient method.
Assessment using this novel catalyst shows promise for expanding the applications of click chemistry beyond traditional copper-based methods.
These findings highlight an alternative pathway for synthesizing triazoles that may reduce limitations posed by existing catalysts.

Implication

This research finds regioselective synthesis of triazoles using 8-hydroxy quinoline, suggesting a Cu-free alternative to traditional click chemistry.

Abstract

Despite numerous reports on Cu-catalysed click reaction and faster rates of reaction using such catalysts, the pharmacological application of this important synthetic method has become limited and hence advancement towards...

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Cite This Study

Bansal et al. (2025) studied this question.

synapsesocial.com/papers/68c1b61454b1d3bfb60eb5d9 https://doi.org/10.1039/d5cy00598a

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8-Hydroxy quinoline catalysed regioselective synthesis of 1,4-disubstituted-1,2,3-triazoles: Realizing Cu-free click chemistry

Key Points

Implication

Abstract

Discussion

Cite This Study

8-Hydroxy quinoline catalysed regioselective synthesis of 1,4-disubstituted-1,2,3-triazoles: Realizing Cu-free click chemistry

Key Points

Implication

Abstract

Discussion

Cite This Study

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