A dual nickel/photoredox catalyzed hydroaminoalkylation of 1,3-dienes is presented. In this atom-economic and energetic protocol, the bulk industrial raw material isoprene and its derivatives are employed as allylic electrophile surrogates, which undergo a coupling with photoredox-generated α-amino alkyl radical species to produce valuable homoallylic amines efficiently. Preliminary mechanism experiments support the intervention of Ni-hydride species that undergo diene insertion to form Ni-allyl intermediates.
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Jin et al. (2025) studied this question.
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