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September 10, 2025Experimental DermatologyOpen Access

Skin Microbiome Under Topical and Systemic Therapeutics in Atopic Dermatitis, a Cross‐Sectional Analysis From ProRaD

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Authors

RRRobin RohayemUniversity of AugsburgMRMatthias ReigerUniversity of AugsburgLRLuise RauerAugsburg University

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Implication

Cross-sectional analysis shows systemic therapy affects S. aureus levels in atopic dermatitis, highlighting treatment alignment challenges.

Key Points

  • Systemic therapy in moderate atopic dermatitis significantly lowers S. aureus abundance compared to local treatment.
  • Analysis involved 464 participants, revealing a strong correlation between AD severity and S. aureus levels in skin swabs.
  • Diagnosis and treatment evaluations were conducted from 2017 to 2019, emphasizing the role of treatment regimens in skin microbiome changes.
  • Findings suggest topical treatments alone do not alter microbial composition, indicating dupilumab may be crucial for microbial management.

Cite This Study

Rohayem et al. (2025) studied this question.

synapsesocial.com/papers/68c1b61454b1d3bfb60eb71ahttps://doi.org/10.1111/exd.70141
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Epidemiology of atopic dermatitis in Europe2019 · 140 citations
  2. 2European guideline (EuroGuiDerm) on atopic eczema: part I – systemic therapy2022 · 425 citations
  3. 3European guideline ( EuroGuiDerm ) on atopic eczema – part II : non‐systemic treatments and treatment recommendations for special AE patient populations2022 · 279 citations
  4. 4Changes in Skin and Nasal Microbiome and Staphylococcal Species Following Treatment of Atopic Dermatitis with Dupilumab2021 · 54 citations
  5. 5Skin microbiome dysbiosis and the role of Staphylococcus aureus in atopic dermatitis in adults and children: A narrative review2023 · 90 citations