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August 1, 2025International Journal of NanomedicineOpen Access

Efficient Colon Cancer Immunogene Therapy Through Co-Delivery of IL-22BP mRNA and Tumor Cell Lysate by CLSV Nanoparticles [Retraction]

Jing Hui Huang Kaiyu Wang Xizi Fu Manfang Zhu Xiaohua Chen Yan Gao Pingchuan Ma Xingmei Duan Ke Men

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Key Points

The co-delivery of IL-22BP mRNA and tumor cell lysate enhances the efficacy of colon cancer therapy using CLSV nanoparticles.
This method shows promise for colon cancer treatment by utilizing a dual approach, potentially improving patient outcomes.
Assessment of this therapy involved utilizing nanoparticles for effective delivery of mRNA and lysate to target cancer cells.
These findings emphasize the importance of innovative delivery methods, which may enhance the effectiveness of immunogene therapies.

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Implication

This approach combines IL-22BP mRNA and tumor cell lysate using CLSV nanoparticles, suggesting potential for improving cancer treatment.

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Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/68c1b81254b1d3bfb60ec082 https://doi.org/10.2147/ijn.s557137

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Dual-mRNA Delivery Using Tumor Cell Lysate-Based Multifunctional Nanoparticles as an Efficient Colon Cancer Immunogene Therapy2024 · 13 citations
2Abstract 4058: Nanoparticle delivery of interleukin-2 induces anti-tumor immune response and therapeutic efficacy in mouse tumor models2024
3Abstract 5737: Enhancing cancer treatment Via a nanostructured chemoimmunotherapy gel facilitating interleukin-2 delivery and immunogenic cell death induction2024
4Abstract B055: Lipid nanoparticle delivery of IL-2 mRNA boosts survival and T cell response in a murine ovarian cancer model2025
5Abstract LB441: An intravenous compatible oncolytic vaccinia virus treated hepatic metastasis of colon cancer through extensive cancer cell killing and activation of cytotoxic effector differentiation2024

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