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September 10, 2025European Journal of ImmunologyOpen Access

Generation of Regulatory T Cells From Human Memory CD4+T Cells by Upregulation of Naked Cuticle Homolog 2

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Authors

JHJiajun HeKOKristy OuMSMichael Schmueck‐Henneresse

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Overview

The novel quinoxaline derivative IFA005 converts human memory CD4+ T cells to suppressive Tregs, indicating enhanced immune tolerance.

Key Points

  • IFA005 converts human memory CD4+ T cells into suppressive Tregs, supporting immune tolerance.
  • Upregulation of naked cuticle homolog 2 reduces glycogen synthase kinase-3β activity, impacting Treg conversion.
  • Identification and characterization of IFA005 involved in inhibiting the Wnt-β-catenin pathway.
  • Findings suggest potential therapeutic strategies for allergic and autoimmune diseases through Treg induction.

Cite This Study

He et al. (2025) studied this question.

synapsesocial.com/papers/68c1b81854b1d3bfb60ec128https://doi.org/10.1002/eji.70018
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