Phylogeny-Guided Discovery of a Promiscuous P450 Macrocyclase for the production of diverse atropopeptides

Bin Tan; Peter Breunig; Lamia Arbib; Yuya Kakumu; Friederike Biermann; Kornelia Hardes; Jasmin K. Hefendehl; Eric J. N. Helfrich

doi:10.1039/d5sc03525b

January 1, 2025Chemical ScienceOpen Access

Phylogeny-Guided Discovery of a Promiscuous P450 Macrocyclase for the production of diverse atropopeptides

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Key Points

The P450 macrocyclase efficiently modifies atropopeptides, enhancing their biocatalytic potential for diverse applications.
Bioactive macrocyclic peptides produced feature C–C or C–N biaryl bridges, offering promising antiviral and anti-inflammatory properties.
Phylogeny-guided approaches facilitated the discovery of a versatile enzyme, highlighting its adaptability in peptide biosynthesis.
The findings underscore the significant implications for pharmaceutical developments involving complex peptide structures.

Implication

Research reveals a substrate promiscuous P450 macrocyclase, indicating potential for diverse macrocyclic peptides in pharmaceuticals.

Abstract

Our findings establish a substrate promiscuous atropopeptide-modifying P450 macrocyclase as a versatile biocatalyst for the biosynthesis of bioactive, C–C or C–N biaryl-bridged macrocyclic peptides with antiviral and anti-inflammatory properties.

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Cite This Study

Tan et al. (2025) studied this question.

synapsesocial.com/papers/68c1b81854b1d3bfb60ec23d https://doi.org/10.1039/d5sc03525b

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Phylogeny-Guided Discovery of a Promiscuous P450 Macrocyclase for the production of diverse atropopeptides

Key Points

Implication

Abstract

Discussion

Cite This Study

Phylogeny-Guided Discovery of a Promiscuous P450 Macrocyclase for the production of diverse atropopeptides

Key Points

Implication

Abstract

Discussion

Cite This Study

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