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September 10, 2025Nature CommunicationsOpen Access

Cross-species comparison reveals therapeutic vulnerabilities halting glioblastoma progression

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Comparison of glioblastoma and murine neural stem cells identifies quiescence and gene expression dysregulation, suggesting new treatment avenues.

A higher quiescence fraction predicts improved outcomes in glioblastoma patients, halting tumor progression.
Analysis reveals activation state architecture as a predictive factor for glioblastoma growth and patient survival.
Assessment utilizes DNA methylation arrays to stratify patients based on activation state and therapeutic targets.
Findings highlight SFRP1's role in reprogramming glioblastoma cells towards an astrocyte-like state for enhanced survival.

Foerster et al. (2025) studied this question.

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Comparison of glioblastoma and murine neural stem cells identifies quiescence and gene expression dysregulation, suggesting new treatment avenues.