Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025Nature CommunicationsOpen Access

IgG autoantibodies in bullous pemphigoid induce a pathogenic MyD88-dependent pro-inflammatory response in keratinocytes

View Full Paper
Ask AI
Bookmark
Share

Authors

LBLei BaoCGChristian F. Guerrero‐JuarezJLJing Li

Discussion

Loading...

Member takes

Overview

Observational analysis reveals IgG autoantibodies induce a pro-inflammatory response in keratinocytes, highlighting implications for bullous pemphigoid pathology.

Key Points

  • A MyD88-dependent pro-inflammatory response occurs in keratinocytes triggered by IgG autoantibodies from BP patients.
  • Cytokines like IL-6 and IL-24 are released, indicating significant inflammatory processes influenced by keratinocyte responses in BP.
  • Using multiplex immunoassays, RNA-seq, and scRNA-seq, the study identifies pathways contributing to BP pathology through keratinocyte activation.
  • Findings suggest keratinocyte-derived inflammation plays a key role in the systemic response to autoantibodies, requiring further exploration.

Cite This Study

Bao et al. (2025) studied this question.

synapsesocial.com/papers/68c1b81854b1d3bfb60ec3aahttps://doi.org/10.1038/s41467-025-62495-2
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Moderated estimation of fold change and dispersion for RNA-seq data with DESeq22014 · 104,581 citations
  2. 2Eosinophilic Infiltrates in Epidermolysis Bullosa1990 · 16 citations
  3. 3MyD88 plays a key role in LPS-induced Stat3 activation in the hypothalamus2009 · 48 citations
  4. 4The Role of Collagen XVII in Cancer: Squamous Cell Carcinoma and Beyond2020 · 56 citations
  5. 5The Metalloprotease-Disintegrin ADAM8 Is Essential for the Development of Experimental Asthma2010 · 84 citations