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September 10, 2025Anatolian Current Medical Journal

Identification of hub genes and enriched pathways in renal ischemia–reperfusion injury via integrative transcriptomic and network analysis

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Authors

PPPerçin PazarcıGEGülşah Evyapan

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Overview

Integrative analysis reveals significant genes and pathways in acute kidney injury, suggesting potential targets for treatment.

Key Points

  • A total of 189 differentially expressed genes were identified, with 117 upregulated and 72 downregulated, indicating significant changes in gene expression.
  • Upregulated genes were mainly involved in pathways related to glutathione metabolism and oxidative stress, while downregulated genes were linked to DNA replication and inflammatory signaling.
  • Analysis involved integrating data from two rat kidney microarray datasets through gene ontology and KEGG enrichment analyses, identifying common differentially expressed genes.
  • The study highlights the role of redox regulation and immune modulation in the pathogenesis of renal ischemia-reperfusion injury, supporting further research on potential biomarkers.

Cite This Study

Pazarcı et al. (2025) studied this question.

synapsesocial.com/papers/68c1b81854b1d3bfb60ec3c7https://doi.org/10.38053/acmj.1713060
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