Chemical characterization, antioxidant capacity, and anti-inflammatory potentials in vitro and in vivo of phenolic compounds extracted from Ajuga iva

Ajuga iva extract has various biological activities and health benefits. Phenolic compounds extracted from medicinal plants are critical molecules in the pharmacotherapy field. Our investigation aimed to determine the chemical composition, antioxidant, and anti-inflammatory activities in vitro and in vivo of Ajuga iva ethanolic extract. Our analysis showed that the ethanolic extract (AIEE) exhibited a high amount of phenolic compounds. In addition, AIEE extract showed high ability to scavenge DPPH● and ABTS•+ free radicals in reaction system. In vitro analysis showed that the AIEE extract revealed a strong anti-inflammatory potential using TPH-1 as a cell model. In vivo investigation revealed that the AIEE extract exhibited strong anti-inflammatory activity. The histopatological observation confirmed the anti-inflammatory activity of AIEE. These results confirmed that AIEE extract could be applied in the pharmaceutical domain