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September 10, 2025Chronic Obstructive Pulmonary Diseases Journal of the COPD FoundationOpen Access

Genetic Evidence for Causal Relationships Between Circulating Cathepsin Levels and Chronic Obstructive Pulmonary Disease: A Mendelian Randomization Study

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Authors

CDChao DuanAZAo ZhangSTSuyan Tian

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Overview

Mendelian randomization analysis found cathepsins O and S as direct causal factors in COPD, suggesting a novel therapeutic target.

Key Points

  • Multivariable MR analysis identified cathepsins O and S as direct causal factors for COPD.
  • Odds ratios for cathepsins O and S were 1.130 (p = 0.022) and 1.068 (p = 0.025) respectively.
  • The study utilized genetic data from the INTERVAL study and FinnGen consortium with nine cathepsins examined.
  • Significant independent effects of cathepsins O and S persisted after controlling for smoking factors.

Cite This Study

Duan et al. (2025) studied this question.

synapsesocial.com/papers/68c1b81f54b1d3bfb60ec60chttps://doi.org/10.15326/jcopdf.2025.0626
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