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September 10, 2025BMC MedicineOpen Access

Sleep quality, APOE ε4, and Alzheimer’s disease: associations from two prospective cohort studies and mechanisms by plasma proteomic analysis

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Authors

LHLin HuangMTMing TanCTChen‐Chen Tan

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Overview

Cohort studies reveal poorer sleep increases Alzheimer's disease risk in non-demented individuals, indicating a link with APOE ε4.

Key Points

  • Poor sleep quality is associated with a higher risk of Alzheimer's disease, highlighting an important health concern.
  • Analysis demonstrated HR of 1.05 in the UK Biobank and HR of 1.37 in the Alzheimer's Disease Neuroimaging Initiative.
  • Linear regression and mixed-effects models were utilized across large cohorts, enhancing the validity of the findings.
  • These insights emphasize the need for future research targeting neuroinflammation in relation to sleep and Alzheimer's.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/68c1b81f54b1d3bfb60ec68fhttps://doi.org/10.1186/s12916-025-04255-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Moderating effect of APOE ε4 on the association of sleep disturbance and amyloid-β pathology among cognitively normal older adults2025
  2. 2APOE4 moderates the association of sleep disturbance with cerebral amyloid burden but not with clinical conversion in cognitively normal older adults2026
  3. 31030 APOE Genotype and Sleep Architecture2024
  4. 40057 APOE4 Genotype and Blunted Homeostatic Sleep EEG in Young Adolescents: An Early Marker of Alzheimer’s Disease Risk?2026
  5. 5Reduced rapid eye movement sleep in late middle-aged and older apolipoprotein E <b>ɛ</b>4 allele carriers2024 · 23 citations