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September 17, 2026Journal of Alzheimer s Disease

APOE4 moderates the association of sleep disturbance with cerebral amyloid burden but not with clinical conversion in cognitively normal older adults

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MLMin Ji LeeJKJihyun KimHCHye Ji Choi

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Lee et al. (2026) studied this question.

synapsesocial.com/papers/6aabb7b85f706d05830e6fcahttps://doi.org/10.1177/13872877261487625
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Moderating effect of APOE ε4 on the association of sleep disturbance and amyloid-β pathology among cognitively normal older adults2025
  2. 2Reduced rapid eye movement sleep in late middle-aged and older apolipoprotein E <b>ɛ</b>4 allele carriers2024 · 23 citations
  3. 31032 Association of Sleep Duration and APOE ε4 Status on Brain Regional Tau Deposition in Clinically Normal Older Adults2024
  4. 41030 APOE Genotype and Sleep Architecture2024
  5. 5Sleep quality, APOE ε4, and Alzheimer’s disease: associations from two prospective cohort studies and mechanisms by plasma proteomic analysis2025