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September 10, 2025CureusOpen Access

Idiosyncratic Drug-Induced Liver Injury in a Patient With Metastatic Melanoma

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Authors

AOAlessandra OttleyATAlison J. ThorntonRGRamon Gil

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Overview

This case report shows drug-induced liver injury in a melanoma patient treated with immunotherapy, suggesting the need for vigilance.

Key Points

  • A 75-year-old male with metastatic melanoma developed drug-induced liver injury, leading to cognitive decline and hospice care.
  • The case illustrates that drug-induced liver injury can occur even with mildly elevated liver enzymes, necessitating close monitoring.
  • Combination therapy involving immunotherapy and hepatotoxic antibiotics likely contributed to the patient's liver toxicity.
  • Early identification of drug-induced liver injury is critical to prevent serious complications and improve patient outcomes.

Cite This Study

Ottley et al. (2025) studied this question.

synapsesocial.com/papers/68c1b81f54b1d3bfb60ec7d2https://doi.org/10.7759/cureus.89482
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