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September 10, 2025Journal of Biological ChemistryOpen Access

The E3 ubiquitin ligase MARCHF8 restricts HSV-1 infection by inhibiting replication of the viral genome.

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Authors

YXYongyan XiaLNL Rayburn NigosFVFernando Villalón‐Letelier

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Overview

Observational analysis shows MARCHF8 restricts HSV-1 replication in human cells, highlighting antiviral mechanisms against DNA viruses.

Key Points

  • MARCHF8 inhibits HSV-1 genomic replication and limits infectious virion release.
  • Detailed assessment revealed that MARCHF8 requires a functional RING-CH domain for antiviral activity against HSV-1.
  • The study utilized a doxycycline-inducible overexpression system to evaluate MARCHF8's role in controlling viral replication.
  • This research highlights a novel mechanism of action for MARCHF8 against human DNA viruses, distinct from its effects on RNA viruses.

Cite This Study

Xia et al. (2025) studied this question.

synapsesocial.com/papers/68c1b81f54b1d3bfb60ec7f7https://doi.org/10.1016/j.jbc.2025.110567
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Elucidating the Antiviral Mechanism of Different MARCH Factors2021 · 40 citations
  2. 2TRIM16 Overexpression in HEK293T Cells Results in Cell Line-Specific Antiviral Activity2023 · 8 citations
  3. 3Herpes Simplex Virus 1 Immediate-Early and Early Gene Expression during Reactivation from Latency under Conditions That Prevent Infectious Virus Production2005 · 88 citations
  4. 4The mitochondrial ubiquitin ligase MARCH5 resolves MAVS aggregates during antiviral signalling2015 · 162 citations
  5. 5Bovine and mouse serum beta inhibitors of influenza A viruses are mannose-binding lectins.1990 · 194 citations