PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
September 10, 2025Cell Death and Differentiation0 citationsOpen Access

ABCC10 Drives Cancer Cell Resistance to Radiotherapy via cGAMP Efflux

ABCC10-mediated cGAMP efflux drives cancer cell radiotherapy resistance

View Full Paper
Ask AI
Bookmark
Share

Authors

ZZZhengyang ZhangJGJie GaoXLXiang Liao

Discussion

Loading...

Member takes

Overview

High-throughput screening identifies ABCC10's role in radiotherapy resistance, suggesting it as a novel therapeutic target.

Key Points

  • ABCC10 effluxes cGAMP, leading to reduced intercellular accumulation of reactive oxygen species.
  • Overexpression and silencing of ABCC10 impacted the STING-TBK1-IRF3 signaling pathway significantly.
  • Combining radiotherapy with nilotinib decreased tumor growth more effectively than either treatment alone.
  • The findings establish ABCC10 as a potential biomarker for predicting responses to radiotherapy.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68c1b82654b1d3bfb60eca50https://doi.org/10.1038/s41418-025-01552-1
View Full Paper
Ask AI
Bookmark
Share