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September 10, 2025Diabetology & Metabolic SyndromeOpen Access

SRPK1 is a significant factor in driving the progression of diabetic kidney fibrosis

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Authors

SHShichao HanSMShuaijun MaKLKepu Liu

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Overview

Observational analysis revealed SRPK1 drives renal fibrosis in diabetic nephropathy, suggesting therapeutic opportunities.

Key Points

  • Inhibition of SRPK1 markedly reduced fibrosis and improved renal function in a mouse model of diabetic nephropathy.
  • SRPK1 expression was significantly elevated in fibrotic kidneys, correlating with increased extracellular matrix components.
  • The use of the selective SRPK1 inhibitor SRPIN340 demonstrated a suppression of fibrotic markers and inflammatory cytokines.
  • Results indicate that SRPK1's role in activating the NF-κB/NLRP3 pathway is crucial in promoting diabetic kidney fibrosis.

Cite This Study

Han et al. (2025) studied this question.

synapsesocial.com/papers/68c1b82654b1d3bfb60ecbe5https://doi.org/10.1186/s13098-025-01889-0
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