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September 10, 2025RSC SustainabilityOpen Access

Sustainable Synthesis of Sulfonamides via Oxidative Chlorination in Alternative Solvents: A general, mild, and Eco-Friendly Strategy

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A new approach enables high-efficiency sulfonamide synthesis using mild conditions and eco-friendly solvents, enhancing sustainability.
The method shows effective conversion of thiols to sulfonyl chlorides, utilizing sodium dichloroisocyanurate as an oxidant.
Oxidative chlorination in sustainable solvents improves the method's environmental footprint, aligning with green chemistry principles.
This technique highlights the potential for scalable applications in pharmaceutical synthesis, fulfilling demands for greener methods.

Implication

A novel method synthesizes sulfonamides using sodium dichloroisocyanurate in sustainable solvents, suggesting improved eco-friendliness.

Abstract

A general, mild, and environmentally friendly method for synthesizing sulfonamides in sustainable solvents was developed. Sodium dichloroisocyanurate dihydrate (NaDCC·2H2O) served as an efficient oxidant for converting thiols to sulfonyl chlorides,...

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Cite This Study

Hernández et al. (2025) studied this question.

synapsesocial.com/papers/68c1bb5b54b1d3bfb60ecc75 https://doi.org/10.1039/d5su00405e

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Implication

A novel method synthesizes sulfonamides using sodium dichloroisocyanurate in sustainable solvents, suggesting improved eco-friendliness.

Sustainable Synthesis of Sulfonamides via Oxidative Chlorination in Alternative Solvents: A general, mild, and Eco-Friendly Strategy

Key Points

Implication

Abstract

Discussion

Cite This Study

Sustainable Synthesis of Sulfonamides via Oxidative Chlorination in Alternative Solvents: A general, mild, and Eco-Friendly Strategy

Key Points

Implication

Abstract

Discussion

Cite This Study

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