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September 10, 2025Transplant InternationalOpen Access

Early Donor-Specific HLA Antibodies Detected by Screening in the First Month Posttransplant and Kidney Graft Outcomes

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Analysis reveals early donor-specific HLA antibodies influence graft loss in transplant patients, suggesting critical screening implications.

Early donor-specific HLA antibodies detected in the first month post-transplant significantly increase risk for graft loss.
Around 8.5% of patients developed early donor-specific HLA antibodies within the first month after transplant.
Multivariable analysis confirmed early donor-specific HLA antibodies are an independent risk factor for antibody-mediated rejection.
Patients with early donor-specific HLA antibodies also exhibit higher levels of HLA sensitization at the time of transplant.

Moral et al. (2025) studied this question.

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Analysis reveals early donor-specific HLA antibodies influence graft loss in transplant patients, suggesting critical screening implications.