Synthesis of zwitterionic compounds reduces α-Synuclein aggregation and phase separation, suggesting potential therapeutic avenues.
Parkinson's disease (PD) is a progressive neurodegenerative condition that affects the brain's ability to control movement. The disease occurs when nerve cells of the brain become impaired. Alpha-synuclein protein (α-Syn) aggregation followed by fibrillation is a hallmark of PD. Recent studies showed that the liquid-liquid phase separation (LLPS) and droplet formation of α-Syn protein play a crucial role in the pathology of PD. We synthesized novel zwitterionic compounds (3), which inhibited α-Syn phase separation and subsequent formation of fibrillary aggregates in a concentration-dependent manner.
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Sarkar et al. (2025) studied this question.
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