Spread Through Air Spaces (STAS) is a pattern of cancer cell invasion found in pulmonary adenocarcinoma and has been identified as a significant independent prognostic factor. The presence of STAS is closely related to an increased risk of local recurrence and a decrease in survival rates, especially in patients undergoing limited resection. This study aims to review the literature related to the prognostic significance and surgical implications of STAS, as well as to evaluate preoperative and intraoperative diagnostic approaches such as CT scans, PET/CT, frozen section, and radiomics. The findings suggest that although the definitive diagnosis of STAS can only be established postoperatively, the development of preoperative predictive technologies is critical in supporting more informed clinical decision-making. It is hoped that STAS can be included in international clinical guidelines to assist in the determination of individualized therapy strategies for lung cancer patients.
Tanujaya et al. (Mon,) studied this question.
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