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September 10, 2025Organic Process Research & Development

Development of a Multigram Preparation of Optically Pure (−)-7-(Bromomethylene)-3-amidobicyclo2.2.1heptane-2-carboxamide BMT-395137, a Versatile Scaffold for Divergent Drug Discovery Synthesis

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Authors

JLJianqing LiDSDaniel SmithLCLyndon A. M. Cornelius

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Overview

This research develops a scalable synthesis of an optically pure compound, indicating its potential as a versatile scaffold for drug discovery.

Key Points

  • The synthesis yields over 100 grams of optically pure BMT-395173, enhancing its utility in drug discovery.
  • A stereoselective Diels–Alder reaction initiates the synthesis, followed by a Wittig reaction that introduces critical functional groups.
  • Using readily available starting materials, the method supports scalable production, paving the way for extensive applications.
  • Divergent drug discovery may benefit from the unique properties of the bicyclic scaffold developed in this research.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68c1bb7054b1d3bfb60ed7bfhttps://doi.org/10.1021/acs.oprd.5c00208
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