Comparison of anti-cancer efficiency of some homeopathic medicines on liver carcinoma cell line HepG2

In India, the prevalence of cancer is continuously rising and among different cancers, males account for about 3.9% of liver carcinoma cases. Statistical analysis revealed position of liver carcinoma within the top 10 cancers among males. Depending on the stage at which the cancer is progressing, there are three possible treatments for hepatic carcinoma: surgical resection which includes hepatectomy and liver transplantation, radiotherapy and ablation. Treatment for metastases is extremely difficult because of the sophisticated surgery required due to the liver's numerous blood vessels and bile duct. Homoeopathy is a notable adjunct treatment method due to its efficaciousness in enhancing the quality of life in cancer patients. In this work, we examined the anti-cancer efficacy of six homeopathic medicines—Calcarea carbonica, Arsenic iodatum, Mercurius vivus, Calcarea phosphorica, Calcarea iodata and Carduus marianus on hepatic carcinoma (HepG2) cell line. The six medications listed were applied to cancer and normal cell lines, together with vehicle control. Tumor necrosis factor α, Interferon γ, Interleukins IL-6, 8, 10, 1β, transforming growth factor β1, were among the targeted cytokines analyzed. In addition to these, cell cytopatheic effect and viability assays were also done following standard protocols. The medications that were chosen based on the aforementioned factors, showed effective anti-cancer action against the HepG2 cell line. Among six medicines tested for anticancer activities against liver cancer cells, this in vitro investigation demonstrated the potential anti-cancer properties of the medicine Calcarea iodata.