Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding (Adv. Sci. 29/2025)

Advanced ScienceVolume 12, Issue 29 71023 FrontispieceOpen Access Eosinophils-Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF-β Pathway Mediated by Anxa1 Binding (Adv. Sci. 29/2025) Wenqian Chen, Wenqian ChenSearch for more papers by this authorYuwei Zhou, Yuwei ZhouSearch for more papers by this authorWenxiu Yuan, Wenxiu YuanSearch for more papers by this authorYanjing Ou, Yanjing OuSearch for more papers by this authorHanyu Lin, Hanyu LinSearch for more papers by this authorKaixun He, Kaixun HeSearch for more papers by this authorXueshen Qian, Xueshen QianSearch for more papers by this authorHuachen Chen, Huachen ChenSearch for more papers by this authorChengchaozi Wang, Chengchaozi WangSearch for more papers by this authorJie Lu, Jie LuSearch for more papers by this authorWeiping Chen, Weiping ChenSearch for more papers by this authorDexiong Li, Dexiong LiSearch for more papers by this authorJiang Chen, Jiang ChenSearch for more papers by this author Wenqian Chen, Wenqian ChenSearch for more papers by this authorYuwei Zhou, Yuwei ZhouSearch for more papers by this authorWenxiu Yuan, Wenxiu YuanSearch for more papers by this authorYanjing Ou, Yanjing OuSearch for more papers by this authorHanyu Lin, Hanyu LinSearch for more papers by this authorKaixun He, Kaixun HeSearch for more papers by this authorXueshen Qian, Xueshen QianSearch for more papers by this authorHuachen Chen, Huachen ChenSearch for more papers by this authorChengchaozi Wang, Chengchaozi WangSearch for more papers by this authorJie Lu, Jie LuSearch for more papers by this authorWeiping Chen, Weiping ChenSearch for more papers by this authorDexiong Li, Dexiong LiSearch for more papers by this authorJiang Chen, Jiang ChenSearch for more papers by this author First published: 07 August 2025 https://doi.org/10.1002/advs.71023AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookxLinkedInRedditWechatBluesky Graphical Abstract Joint Osteoarthritis Eosinophils are crucial in the progression of temporomandibular joint osteoarthritis (TMJOA). In article number 2416030, Jiang Chen and co-workers show OVA/IL-5-induced eosinophils promote synovial Lumican, which binds chondrocyte Anxa1 to inhibit TGFβ2/Smad2/3 signaling. This reduces cartilage matrix degradation, synovitis, and bone erosion, delaying TMJOA. Eosinophil-stimulated Lumican emerges as a promising therapeutic target for TMJOA treatment. Volume12, Issue29August 7, 202571023 RelatedInformation