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September 10, 2025Radiology Cardiothoracic ImagingOpen Access

Hyperpolarized 129Xe MRI and Spectroscopy: Quantitative Measurements, Results, and Emerging Opportunities

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Authors

ASA. SchmidtJLJackie LigginsHBHaad Bhutta

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Overview

This review reports on 129Xe MRI's capabilities in measuring pulmonary function, suggesting emerging utility in cardiopulmonary disease management.

Key Points

  • Quantitative measurements from hyperpolarized 129Xe MRI aid in detecting pulmonary function deficits and other conditions.
  • Established correlations with pulmonary function tests validate 129Xe MRI measurements in various cardiopulmonary diseases.
  • Gas exchange imaging using hyperpolarized 129Xe emphasizes the importance of assessing blood oxygenation in evaluation.
  • The ability to visualize regional lung function provides new opportunities for targeted interventions in lung disease.

Cite This Study

Schmidt et al. (2025) studied this question.

synapsesocial.com/papers/68c1bb7054b1d3bfb60ed9e1https://doi.org/10.1148/ryct.240562
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized <sup>129</sup>Xe MRI to Evaluate Lung Structure-Function2024 · 2 citations
  2. 2Direct imaging of pulmonary gas exchange in vivo with hyperpolarized xenon MRI2025
  3. 3Hyperpolarized 129Xe MRI : a new option for navigating respiratory interventions2025
  4. 4Free-Breathing Hyperpolarized Xenon-129 Spectroscopy with Cardiopulmonary Gating2024
  5. 5Hyperpolarized 129Xe Gas Exchange MRS in Mice: Impact of Heart Rate, Ventilation Pressure, and a Paralytic on Cardiogenic Signal Oscillations2025