High GABA-producing Lactococcus lactis ZFM559 and its derived GABA alleviates chronic unpredictable mild stress (CUMS)-induced depression via the “microbiota-brain” axis

Jiarun Han; Shi Hu; Xiaohan Zhao; Lina Ding; Jiaqi Yin; Jiaqi Liu; Ping Li; Qing Gu

doi:10.1039/d5fo02582f

January 1, 2025Food & Function

High GABA-producing Lactococcus lactis ZFM559 and its derived GABA alleviates chronic unpredictable mild stress (CUMS)-induced depression via the “microbiota-brain” axis

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Key Points

GABA alleviates depression associated with chronic unpredictable mild stress, demonstrating potential as a therapeutic agent.
Research indicates that Lactococcus lactis ZFM559 produces high levels of GABA, with implications for mental health interventions.
The study focuses on the relationship between GABA, the microbiota-brain axis, and depression, across various settings.
Findings highlight that GABA's efficacy may be influenced by its ability to cross the blood-brain barrier, warranting further investigation.

Implication

Observational analysis shows GABA reduces depression in models with chronic unpredictable mild stress, suggesting a microbiota-brain connection.

Abstract

γ-aminobutyric acid (GABA) is a crucial inhibitory neurotransmitter with recognized benefits in alleviating depression. However, the ability of exogenous GABA to cross the blood-brain barrier remains debated, and the underlying...

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Cite This Study

Han et al. (2025) studied this question.

synapsesocial.com/papers/68c1bb7054b1d3bfb60eda3b https://doi.org/10.1039/d5fo02582f

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High GABA-producing Lactococcus lactis ZFM559 and its derived GABA alleviates chronic unpredictable mild stress (CUMS)-induced depression via the “microbiota-brain” axis

Key Points

Implication

Abstract

Discussion

Cite This Study

High GABA-producing Lactococcus lactis ZFM559 and its derived GABA alleviates chronic unpredictable mild stress (CUMS)-induced depression via the “microbiota-brain” axis

Key Points

Implication

Abstract

Discussion

Cite This Study

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