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This is a Systematic Review study.

September 10, 2025Journal of Forensic SciencesOpen Access

Beyond the numbers: Critical analysis of the role of postmortem tryptase in the forensic diagnosis of anaphylaxis

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Systematic review of tryptase and its potential as a biomarker for anaphylaxis, indicating diagnostic challenges.

Elevated tryptase levels support anaphylaxis diagnosis postmortem, but reliability is limited by heterogeneous methodologies.
Biochemical studies report diagnostic thresholds for tryptase levels between 30.4 and 64 μg/L, with 53.8 μg/L showing strong discriminative capacity.
Immunohistochemical analyses show increased tryptase-positive mast cells in anaphylaxis cases, yet lack standardized quantification methods.
Elevated tryptase levels can also appear in non-anaphylactic deaths, highlighting the need for standardized protocols in forensic diagnosis.

Tomassini et al. (2025) studied this question.

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