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September 10, 2025Nature CommunicationsOpen Access

Urinary Complement proteome strongly linked to diabetic kidney disease progression

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Analysis reveals urinary Complement proteome's strong association with kidney failure risk in diabetic cohorts, suggesting diagnostic potential.

Increased urinary Complement proteins significantly correlate with kidney failure risk over a decade.
Top 5% urinary proteins include key components of the Complement system, indicating robust associations.
Assessment includes two prospective cohorts totaling 1,804 person-years, focusing on diabetes types 1 and 2.
Findings provide groundwork for biomarker-guided treatments in diabetic kidney disease management.

Dom et al. (2025) studied this question.

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Analysis reveals urinary Complement proteome's strong association with kidney failure risk in diabetic cohorts, suggesting diagnostic potential.