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September 10, 2025Cancer ReportsOpen Access

Multiple Skin Cancers Associated With Hydroxyurea: Case Report and Review of Literature

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Authors

SSSafoura ShakoeiZNZahra Nilfroushan

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Overview

Case report details multiple skin cancers in an ET patient, suggesting long-term HU therapy may increase risks.

Key Points

  • A 54-year-old woman developed multiple skin cancers, including SCCs, after long-term hydroxyurea therapy.
  • Literature review of 60 cases shows SCCs were the most common skin cancers linked to hydroxyurea treatment.
  • Patients had a mean latency period of 7.33 years before symptoms of skin cancer manifested.
  • Further awareness is needed among healthcare providers for early detection and preventive measures during HU therapy.

Cite This Study

Shakoei et al. (2025) studied this question.

synapsesocial.com/papers/68c1bd3254b1d3bfb60ee451https://doi.org/10.1002/cnr2.70304
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical Insights and Dermatological Recommendations for Non-Melanoma Skin Cancers (NMSCs) in Long-Term Hydroxyurea (HU) Therapy2024 · 3 citations
  2. 2A patient case highlighting the myriad of cutaneous adverse effects of prolonged use of hydroxyurea2017 · 16 citations
  3. 3Nonmelanoma skin cancer associated with Hydroxyurea treatment: Overview of the literature and our own experience2019 · 45 citations
  4. 4Skin Changes Secondary to Hydroxyurea Therapy1975 · 186 citations