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September 10, 2025Medical PhysicsOpen Access

Framework to calculate 225Ac, 177Lu, and 161Tb radiation dose and biological effect in metastatic castration‐resistant prostate cancer treatment

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Observational analysis compares radiation dose and biological effects of 225 Ac and 177 Lu in mCRPC, revealing key therapeutic insights.

Microscopic analysis shows 225 Ac induces significantly higher DNA breaks compared to 177 Lu and 161 Tb.
Crossfire effects impact treatment efficacy: 75% for 225 Ac, highlighting its localized killing potential.
Monte Carlo simulations estimate dose absorption, revealing higher cellular doses than macro-scale estimations.
Mathematical frameworks like BECK enhance precision in comparing biological effects across different radionuclides.

Ghaseminejad et al. (2025) studied this question.

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