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September 10, 2025Scientific ReportsOpen Access

Combining single-cell and bulk RNA sequencing to identify CAF-related signature for prognostic prediction and treatment response in patients with melanoma

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A 28-gene CAF signature predicts survival in melanoma, showing strong accuracy for 1-year, 3-year, and 5-year outcomes.
Area under the curve (AUC) values of 0.737, 0.737, and 0.779 indicate the signature’s strong predictive power for patient survival.
The study utilizes ScRNA-seq data to validate CAF expressions in clinical melanoma samples, indicating its relevance in the tumor microenvironment.
CAF signatures revealed correlations with copy number variations and immune cell profiles, highlighting the complexity of their roles in treatment response.

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Research demonstrates a CAF-related risk signature for prognosis and treatment response in melanoma, suggesting potential clinical applications.

Wang et al. (2025) studied this question.

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Research demonstrates a CAF-related risk signature for prognosis and treatment response in melanoma, suggesting potential clinical applications.